The concept of very True GE-algebra using very True operator is introduced and its properties are studied to expand the scope of research of GE-algebras. The concepts of simple very True GE-algebra and very True GE-filter are introduced. The characterization of simple very True GE-algebra is discussed, and several properties on very True GE-filter are investigated. Using a very True GE-filter, the quotient very True GE-algebra is constructed, and the uniform and topological space are established.

Aspirin (acetylsalicylic acid; ASA) is one of the most commonly used drugs, Studies have showed that low dose ASA can reduce cardiovascular events by irreversibly binding to cyclooxygenase and inhibiting platelet aggregation. However, ASA has not prevented all patients from cardiovascular events [1]. Ackerman and Newman were the first to describe the phenomenon of Aspirin resistance (AR) in 1990, named "incomplete antiplatelet effect of aspirin". Afterwards, in the last two decades, several studies have demonstrated that some people do not respond to low dose aspirin as an anti-platelet [2].